In the probiotic Escherichia coli strain Nissle 1917 and its recent clonal isolates, CsgD activates the production of curli fimbriae at 28 degrees C, but neither CsgD nor AdrA is required for the c-di-GMP-dependent biosynthesis of cellulose at 28 degrees C and 37 degrees C.
This work genetically engineer E. coli Nissle 1917 to create a fibrous matrix that has a protective effect in DSS-induced colitis mice, and lays a foundation for the development of a platform in which the in situ production of therapeutic protein matrices from beneficial bacteria can be exploited. Mucosal healing plays a critical role in combatting the effects of inflammatory bowel disease
In conclusion, we have provided evidence that the probiotic E. coli strain Nissle 1917 as well as other probiotic strains suppresses TNF-α-induced IL-8 secretion from IECs. Moreover, the mechanism by which Nissle 1917 suppresses IL-8 might be independent of the inhibition of the NF-κB signaling pathway.
The parent strain chosen for development of our BG delivery system is the probiotic Escherichia coli strain Nissle 1917 (EcN), whose intrinsic properties trigger the innate immune system with the flagella and fimbriae used to attach and stimulate epithelial cells. In previous studies, we have shown that EcN BGs are safe for the ocular surface
This study investigated the ability of probiotic Escherichia coli Nissle 1917 (EcN) to outcompete the biofilm formation of pathogens including enterohemorrhagic E. coli (EHEC), Pseudomonas aeruginosa, Staphylococcus aureus, and S. epidermidis.
Escherichia coli Nissle 1917 (EcN) strain is a Gram-negative strain isolated from a young German soldier who were not infected with Shigella during the endemic period at World War I. The probiotic drug Mutaflor ® using this EcN is available and used in managing gastrointestinal disorders including diarrhea, uncomplicated diverticular disease Escherichia coli Nissle 1917 (EcN) has been proven to be operative for curing the inflammatory intestinal illnesses [ 16 – 18] and acute diarrhea [ 19 ]. EcN is a nonpathogenic gram-negative strain utilized in numerous gastrointestinal issues consisting of diarrhea [ 20 ], uncomplicated diverticular malady [ 21] and IBD, specifically UC [ 22 ]. The K5 capsule of Escherichia coli strain Nissle 1917 is important in mediating interactions with intestinal epithelial cells and chemokine induction. Infect. Immun. 77 , 2995–3003 (2009). 98XAoQx.
